Sudan virus disease outbreak in Uganda in 2022: the case of patient zero

•Ebola disease outbreak in Uganda in 2022.•Clinical course of the first hospitalized patient with Sudan virus disease.•Sudan virus disease has a high mortality rate. In 2000, Uganda reported the first Ebola disease outbreak, and since then, the nation has had several other outbreaks. On September 15, 2022, a Ugandan man aged 24 years presented with a history of fever, hematemesis, and hematochezia. A clinical suspicion of a viral hemorrhagic fever was raised, the patient was isolated, and the authorities were notified. Clinical samples subjected to real-time polymerase chain reaction analysis confirmed Sudan virus disease (SVD) caused by the Sudan Ebola virus species. The patient died 3 days later. By November 30, 2022, there had been a total of 142 confirmed cases of SVD in Uganda, with 56 (39.4%) fatalities. The case described in this report is the first patient who was hospitalized during this outbreak. SVD has a high mortality rate despite the best supportive management. Therefore, it is important to focus on preventive measures to control outbreaks of this disease.