Amphibian skin bacteria display antifungal activity and induce plant defense mechanisms against Botrytis cinerea

is the causal agent of gray mold, which affects a wide variety of plant species. Chemical agents have been used to prevent the disease caused by this pathogenic fungus. However, their toxicity and reduced efficacy have encouraged the development of new biological control alternatives. Recent studies have shown that bacteria isolated from amphibian skin display antifungal activity against plant pathogens. However, the mechanisms by which these bacteria act to reduce the effects of are still unclear. From a diverse collection of amphibian skin bacteria, three proved effective in inhibiting the development of under conditions. Additionally, the individual application of each bacterium on the model plant and post-harvest blueberries significantly reduced the disease caused by . To understand the effect of bacteria on the host plant, we analyzed the transcriptomic profile of in the presence of the bacterium C32I and the fungus , revealing transcriptional regulation of defense-related hormonal pathways. Our study shows that bacteria from the amphibian skin can counteract the activity of by regulating the plant transcriptional responses.