LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors

Long non-coding RNAs (lncRNAs) play an important role in the regulation of key cellular processes in early development and cancer. LncRNA Oip5-as1 facilitates stem cell self-renewal in mouse by sponging mmu-miR-7 and modulating NANOG level, yet its role in cancer is less understood. We analyzed OIP5...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.7018-13, Article 7018
Hauptverfasser:	Arunkumar, Ganesan, Anand, Shankar, Raksha, Partha, Dhamodharan, Shankar, Prasanna Srinivasa Rao, Harikrishnan, Subbiah, Shanmugam, Murugan, Avaniyapuram Kannan, Munirajan, Arasambattu Kannan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 38/39 38/47 38/77 38/90 631/208/177 631/208/199 631/67/69 Binding sites Cancer Cell self-renewal Humanities and Social Sciences KLF4 protein multidisciplinary Myc protein Oral cancer Post-transcription Science Science (multidisciplinary) Stem cells Transcription factors Tumors
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Zusammenfassung:	Long non-coding RNAs (lncRNAs) play an important role in the regulation of key cellular processes in early development and cancer. LncRNA Oip5-as1 facilitates stem cell self-renewal in mouse by sponging mmu-miR-7 and modulating NANOG level, yet its role in cancer is less understood. We analyzed OIP5-AS1 expression in oral tumors and in TCGA datasets. We observed overexpression of OIP5-AS1 in oral tumors ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-25451-3