COMPARACION DE DIFERENTES APROXIMACIONES PARA ESTIMAR LIMITES DE DETECCION EN ANALISIS DE RESIDUOS DE PLAGUICIDAS EN ALIMENTOS

The limit of detection (LOD) calculation is a practice that has generated several discussions in the scientic community, due to different denitions and procedures for its estimation. The fundamental objective of the present work is to apply, conrm and compare six different recommendations suggested by ofcial guidelines for the estimation of LOD of 31 pesticide residues in ve different commodities using the QuEChERS method and ultra fast liquid chromatography coupled to mass spectrometry. The methods evaluated were IUPAC, EPA, t99, root mean square error (RMSE), Hubaux- Vos and propagation of errors. In this study it was found that limits of detection of the different approaches did not show a signicant variation with the commodities tested, excluding the method of EPA. On the other hand, t99, RMSE and Hubaux methods showed the lowest signal to noise ratio (S/N