Copper-catalyzed intermolecular Regio- and Enantioselective Hydrosilylation of Alkenes with Prochiral Silanes

This study presents a copper-catalyzed, substrate-controlled regio- and enantioselective intermolecular hydrosilylation method capable of accommodating a broad scope of alkenes and prochiral silanes. The approach offers an efficient and versatile pathway to generate enantioenriched linear and branched alkyl-substituted Si-stereogenic silanes. Key features of this reaction include mild reaction conditions, simple catalytic systems, compatibility with diverse substrates, high yields and enantioselectivities. While methods to create chiral carbon centers and stereochemically defined silicon centers have been developed, the ability to generate both simultaneously would be of high value. Here the authors present a copper-catalyzed, substratecontrolled regio- and enantioselective intermolecular hydrosilylation capable of accommodating a broad scope of alkenes and prochiral silanes.