Quantification Accuracy of Liver Fibrosis by In Vivo Elastography and Digital Image Analysis of Liver Biopsy Histochemistry

Chronic hepatitis C is a rapidly spreading infection and continues to be leading cause of chronic liver disease. Liver fibrosis staging is essential in management on these patients. The accurate assessment of hepatic fibrosis plays an important role for determining treatment, screening strategies, and prognosis. The aim of this study was to evaluate accuracy of noninvasive transient elastography and three digital image analysis tools, for measuring the extent of fibrosis in human liver biopsies, based on the biopsy fibrosis reference data obtained by stereological point counting method.