Association between circulatory complement activation and hypertensive renal damage: a case-control study

Association between circulatory complement activation and hypertensive renal damage: a case-control study

The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage. Serum complement C3, complement Factor H (CFH) and AP activation were assessed in...

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Veröffentlicht in:Renal failure 2024-12, Vol.46 (2), p.2365396
Hauptverfasser: Wang, Zhongli, Zhang, Tingting, Wang, Xinyu, Zhai, Jianlong, He, Lili, Ma, Sai, Zuo, Qingjuan, Zhang, Guorui, Guo, Yifang
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
alternative complement pathway (AP)
Case-Control Studies
CFH
Complement Activation
complement C3
Complement C3 - analysis
Complement C3 - metabolism
Complement Factor H
Complement Pathway, Alternative
Complement system
Disease Progression
Essential Hypertension - blood
Essential Hypertension - complications
Essential Hypertension - physiopathology
Female
Humans
Hypertension - blood
Hypertension - complications
Hypertension and Volume Management
hypertensive renal damage
Logistic Models
Male
Middle Aged
Risk Factors
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Zusammenfassung:The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage. Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected. Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (  
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2024.2365396