Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields u...
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Veröffentlicht in: | Anais da Academia Brasileira de Ciências 2021-01, Vol.93 (3), p.e20201347-e20201347 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C). |
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ISSN: | 0001-3765 1678-2690 1678-2690 |
DOI: | 10.1590/0001-3765202120201347 |