Legg-Calve-Perthes Disease in Two Generations of Male Family Members: A Case Report

Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs i...

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Veröffentlicht in:	Journal of orthopaedic surgery (Hong Kong) 2013-08, Vol.21 (2), p.258-261
Hauptverfasser:	Al-Omran, Ammar K, Sadat-Ali, Mir
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Child Collagen Type II - genetics Families & family life Genes Genetic Predisposition to Disease Hip joint Humans Legg-Calve-Perthes Disease - diagnostic imaging Legg-Calve-Perthes Disease - genetics Male Mutation Pain Proteins Radiography
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Zusammenfassung:	Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs in any family member, we recommend genetic analysis and counselling as well as early radiological screening of related children.
ISSN:	1022-5536 2309-4990
DOI:	10.1177/230949901302100230