Prognostic factors and outcomes in COVID-19 patients requiring prolonged mechanical ventilation: a retrospective cohort study

Background: Mechanical ventilation (MV) in coronavirus disease 2019 (COVID-19) patients is associated with high mortality and extensive resource utilization. The aim of this study was to investigate prognostic factors and outcomes associated with prolonged mechanical ventilation (PMV) in COVID-19 pa...

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Veröffentlicht in:Therapeutic advances in respiratory disease 2022-03, Vol.16, p.17534666221086415-17534666221086415
Hauptverfasser: Melamed, Roman, Paz, Francisco, Jepsen, Stacy, Smith, Claire, Saavedra, Ramiro, Mulder, Maximilian, Masood, Adnan, Huelster, Joshua, Kirkland, Lisa, Guenther, Alena, Boland, Lori
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Sprache:eng
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Zusammenfassung:Background: Mechanical ventilation (MV) in coronavirus disease 2019 (COVID-19) patients is associated with high mortality and extensive resource utilization. The aim of this study was to investigate prognostic factors and outcomes associated with prolonged mechanical ventilation (PMV) in COVID-19 patients. Methods: This was a retrospective cohort study of COVID-19 patients requiring invasive MV who were hospitalized between 1 March 2020 and 30 June 2021 in the intensive care units (ICUs) of three referral hospitals belonging to a single health system. Data were extracted from electronic health records. PMV was defined as  > 17 days of MV. Results: Of 355 patients studied, 86 (24%) required PMV. PMV patients had lower PaO2/FiO2 ratio, higher PCO2, and higher plateau and driving pressures during the first 2 weeks of MV than their short MV (SMV; ⩽ 17 days) counterparts. PMV patients received more proning, neuromuscular blockade, and tracheostomy, had longer ICU and hospital length of stay (LOS), and required discharge to an inpatient rehabilitation facility more frequently (all p  6, and week 2 PaO2/FiO2 ratio 
ISSN:1753-4666
1753-4658
1753-4666
DOI:10.1177/17534666221086415