Inhibition of the protective effects of preconditioning in ischemia–reperfusion injury by chronic methadone: the role of pAkt and pSTAT3

Cardiac ischemic preconditioning (Pre) reduces cardiac ischemia–reperfusion injury (IRI) by stimulating opioid receptors. Chronic use of opioids can alter the signaling pathways. We investigated the effects of chronic methadone use on IRI and Pre. The experiments were performed on isolated hearts of...

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Veröffentlicht in:	Scientific reports 2024-06, Vol.14 (1), p.14350-9, Article 14350
Hauptverfasser:	Yeganeh-Hajahmadi, Mahboobeh, Kordestani, Zeinab, Moosavi-Saeed, Yasmin, Rostamzadeh, Farzaneh
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443 692/4019 AKT protein Animals Heart Humanities and Social Sciences Ischemia Ischemia–reperfusion injury Ischemic preconditioning Ischemic Preconditioning, Myocardial - methods Isolated heart Male Methadone Methadone - pharmacology multidisciplinary Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Opioid receptors Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control RISK (reperfusion injury salvage kinase) SAFE (survivor activating factor enhancement) Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Stat3 protein STAT3 Transcription Factor - metabolism
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Zusammenfassung:	Cardiac ischemic preconditioning (Pre) reduces cardiac ischemia–reperfusion injury (IRI) by stimulating opioid receptors. Chronic use of opioids can alter the signaling pathways. We investigated the effects of chronic methadone use on IRI and Pre. The experiments were performed on isolated hearts of male Wistar rats in four groups: IRI, Methadone + IRI (M-IRI), Pre + IRI (Pre-IRI), Methadone + Pre + IRI (M-Pre-IRI). The infarct size (IS) in the Pre-IRI group was smaller than the IRI group (26.8% vs. 47.8%, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-65349-x