Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. Th...

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Veröffentlicht in:	Beilstein journal of organic chemistry 2017-01, Vol.13 (1), p.19-25
Hauptverfasser:	Mascitti, Andrea, Lupacchini, Massimiliano, Guerra, Ruben, Taydakov, Ilya, Tonucci, Lucia, d'Alessandro, Nicola, Lamaty, Frederic, Martinez, Jean, Colacino, Evelina
Format:	Artikel
Sprache:	eng
Schlagworte:	1,1’-carbonyldiimidazole (CDI) Additives ball-milling Chemical Sciences Chemistry Full Research Paper Glycerol hydantoins Investigations liquid-assisted grinding (LAG) mechanochemistry Molecular weight Organic chemistry poly(ethylene) glycols (PEGs) Polyethylene glycol Polymers Stainless steel Viscosity
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Beschreibung
Zusammenfassung:	The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
ISSN:	1860-5397 2195-951X 1860-5397
DOI:	10.3762/bjoc.13.3