Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis

Introduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefor...

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Veröffentlicht in:	Basic and clinical neuroscience 2009-10, Vol.1 (1), p.3-6
Hauptverfasser:	Mehdizadeh, Mehdi, Mohammad Taghi Joghataei, Nobakht, Maliheh, Aryanpour, Roya
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Antioxidants Dopamine receptors Flavonoids Movement disorders Neostriatum Neurodegeneration Neurodegenerative diseases Neurons Neuroprotection Neurotoxicity Parkinson's disease Quercetin Rat Rodents Substantia nigra Surgery Toxicity
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Zusammenfassung:	Introduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated. Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p
ISSN:	2008-126X 2228-7442