SRC-2 Coactivator: a role in human metabolic evolution and disease

SRC-2 Coactivator: a role in human metabolic evolution and disease

The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary 'master genes' to direct the coordinate transcription of multiple genes required for physiological goals in cell...

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Veröffentlicht in:Molecular Medicine 2020-05, Vol.26 (1), p.45-45, Article 45
1. Verfasser: O'Malley, Bert W
Format: Artikel
Sprache:eng
Schlagworte:
Body fat
Cancer
Cholesterol
Coactivators
Diabetes
Efficiency
Energy
Evolution
Fatty acids
Food
Gene amplification
Gene expression
Genes
Glucose
Lipids
Metabolism
Metastasis
Obesity
Oils & fats
Physiological aspects
Pregnancy
SRC-2
Transcription (Genetics)
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Beschreibung
Zusammenfassung:The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary 'master genes' to direct the coordinate transcription of multiple genes required for physiological goals in cells, specifically, carbohydrate, lipid, or anabolic growth metabolisms. SRC-2 is of special interest in terms of lipid metabolism and energy accrual and is the topic of a collection of our research discoveries and publications described in this Perspective.
ISSN:1076-1551
1528-3658
DOI:10.1186/s10020-020-00168-0