Current approaches to medication correction of autonomic dysfunction syndrome in children

The scientific review presents modern approaches to the treatment of autonomic dysfunction syndrome in children. For writing the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Glo­bal Health, The Cochrane Library, CyberLeninka databases. The main clinical manifestations and pathophysiological mechanisms of autonomic dysfunction syndrome in children are presented. It is emphasized that for the treatment of autonomic dysfunction syndrome in children, one of the recommended and effective is the herbal drug Cratal for children (PJSC SIC “Borshchahivskyi CPP”), which has a sedative, cardio- and neuroprotective effect. One tablet of Cratal for children contains 21.5 mg of hawthorn fruit extract (Crataegus oxyacantha), 43.5 mg of motherwort extract (Leonurus cardiaca) and 433.5 mg of taurine. The features of taurine influence on the cardiovascular system, on the deve­lopment of the inflammatory process, on the muscular system are reflected. It has been stated that the sedative effect of alkaloids (leonurine, stachydrine) of motherwort extract is due to an increased inhibition or reduction of the excitatory process in the central nervous system. It is revealed that hawthorn has anti-inflammatory properties by preventing the synthesis and release of inflammatory activators such as histamine, serine proteases, prostaglandins, leukotrienes. The results of scientific researches conducted in Ukraine on the possibility of using the drug Cratal for children in the treatment of autonomic dysfunction syndrome are presented. Thus, the drug Cratal for children, developed by the specialists of PJSC SIC “Borshchahivskyi CPP”, is well-tolerated, has no toxic effect and does not cause allergic reactions, it is effective and safe in the treatment of various types of autonomic dysfunction syndrome in children and adolescents. Cratal for children is the drug of choice for children with autonomic dysfunction syndrome who have arterial hypertension, cardiac arrhythmias, sleep disorders, emotional lability.