Oral transmission of L-type bovine spongiform encephalopathy in primate model

We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-a...

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Veröffentlicht in:	Emerging infectious diseases 2012-01, Vol.18 (1), p.142-145
Hauptverfasser:	Mestre-Francés, Nadine, Nicot, Simon, Rouland, Sylvie, Biacabe, Anne-Gaëlle, Quadrio, Isabelle, Perret-Liaudet, Armand, Baron, Thierry, Verdier, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal Feed Animals Bovine spongiform encephalopathy Brain - pathology BSE Cattle Cheirogaleidae Creutzfeldt-Jakob disease Dispatch Encephalopathy, Bovine Spongiform - classification Encephalopathy, Bovine Spongiform - transmission Female L-type BSE Lemurs Life Sciences Male Medical research Medicine, Experimental mouse lemur Neurobiology Neurons and Cognition prion Prions Prions - metabolism prions and related diseases
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Zusammenfassung:	We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1801.111092