Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis

To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients. The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific su...

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Veröffentlicht in:	Journal of cardiothoracic surgery 2024-12, Vol.19 (1), p.685-9, Article 685
Hauptverfasser:	Jiang, Jiao, Li, Hongjuan, Chen, Lin, Qiu, Xiaoming
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumin-bilirubin grade Bilirubin Bilirubin - blood Blood Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Diagnosis Health aspects Humans Lung cancer Lung Neoplasms - blood Lung Neoplasms - mortality Lung Neoplasms - pathology Measurement Medical examination Meta-analysis Pretreatment Prognosis Serum Albumin - analysis Serum Albumin - metabolism Survival
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Zusammenfassung:	To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients. The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were combined and subgroup analysis based on the type of lung cancer [non-small cell lung cancer (NSCLC) vs. small cell lung cancer (SCLC)] and treatment [surgery vs. immune checkpoint inhibitors (ICIs) vs. chemotherapy] was conducted. Eight studies with 2,057 patients were included. Pooled results indicated that elevated pretreatment ALBI grade was significantly related to poor OS (HR = 2.50, 95% CI: 2.03-3.09, P
ISSN:	1749-8090 1749-8090
DOI:	10.1186/s13019-024-03311-8