Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, Haiti

Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected. Among 49 patients with falciparum malaria, we found neither parasites carrying haplotypes associated with chloroquine r...

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Veröffentlicht in:	Emerging infectious diseases 2012-09, Vol.18 (9), p.1487-1489
Hauptverfasser:	Neuberger, Ami, Zhong, Kathleen, Kain, Kevin C, Schwartz, Eli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis Antimalarials - therapeutic use Child chloroquine Chloroquine - therapeutic use Dispatch Drug Resistance - genetics Expedited Female Haplotypes Humans Malaria Malaria, Falciparum - diagnosis Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Male Membrane Transport Proteins - genetics Mutation parasite Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Protozoan Proteins - genetics resistance susceptibility Young Adult
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Zusammenfassung:	Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected. Among 49 patients with falciparum malaria, we found neither parasites carrying haplotypes associated with chloroquine resistance nor instances of chloroquine treatment failure. Continued vigilance to detect emergence of chloroquine resistance is needed.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1809.120605