Dyads of GGC and GCC form hotspot colonies that coincide with the evolution of human and other great apes

GGC and GCC short tandem repeats (STRs) are of various evolutionary, biological, and pathological implications. However, the fundamental two-repeats (dyads) of these STRs are widely unexplored. On a genome-wide scale, we mapped (GGC)2 and (GCC)2 dyads in human, and found monumental colonies (distanc...

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Veröffentlicht in:	BMC genetics 2024-02, Vol.25 (1), p.21-21, Article 21
Hauptverfasser:	Arabfard, M, Tajeddin, N, Alizadeh, S, Salesi, M, Bayat, H, Khorram Khorshid, H R, Khamse, S, Delbari, A, Ohadi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	(GCC)2 (GGC)2 Alzheimer's disease Apes Chromosome 2 Chromosome 20 Chromosome 9 Chromosomes Colonies Colony Datasets Evolution Evolutionary biology Genetic aspects Genomes Genomics Great ape Growth Human Human evolution humans Periodicity probability Pseudogenes Recombination hot spots Recombination hotspot Short tandem repeats Software packages Statistical analysis
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Beschreibung
Zusammenfassung:	GGC and GCC short tandem repeats (STRs) are of various evolutionary, biological, and pathological implications. However, the fundamental two-repeats (dyads) of these STRs are widely unexplored. On a genome-wide scale, we mapped (GGC)2 and (GCC)2 dyads in human, and found monumental colonies (distance between each dyad
ISSN:	2730-6844 2730-6844 1471-2156
DOI:	10.1186/s12863-024-01207-z