Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lea...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2006-12, Vol.11 (12), p.968-977
Hauptverfasser:	Sechi, Mario, Casu, Fabio, Campesi, Ilaria, Fiori, Stefano, Mariani, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	AB2 monomers Acids antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological activity Cell Line Communication DHICA HIV-1 HIV-1 - drug effects Humans Hyperbranched polymers Indoles - chemistry Indoles - pharmacology Microbial Sensitivity Tests Polymers
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Beschreibung
Zusammenfassung:	In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/11120968