Peptide Shuttles for Blood–Brain Barrier Drug Delivery

Peptide Shuttles for Blood–Brain Barrier Drug Delivery

The blood–brain barrier (BBB) limits the delivery of therapeutics to the brain but also represents the main gate for nutrient entrance. Targeting the natural transport mechanisms of the BBB offers an attractive route for brain drug delivery. Peptide shuttles are able to use these mechanisms to incre...

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Veröffentlicht in:Pharmaceutics 2022-09, Vol.14 (9), p.1874
Hauptverfasser: Sánchez-Navarro, Macarena, Giralt, Ernest
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Antibodies
BBB–peptide shuttle
Blood-brain barrier
brain delivery
Chemical properties
Drug delivery systems
Drugs
Enzymes
Hazardous materials
Health aspects
Materials
Peptides
Physiological aspects
Product development
Proteins
Review
Shuttles
Vehicles
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Zusammenfassung:The blood–brain barrier (BBB) limits the delivery of therapeutics to the brain but also represents the main gate for nutrient entrance. Targeting the natural transport mechanisms of the BBB offers an attractive route for brain drug delivery. Peptide shuttles are able to use these mechanisms to increase the transport of compounds that cannot cross the BBB unaided. As peptides are a group of biomolecules with unique physicochemical and structural properties, the field of peptide shuttles has substantially evolved in the last few years. In this review, we analyze the main classifications of BBB–peptide shuttles and the leading sources used to discover them.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14091874