NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2020-06, Vol.10 (6), p.904
Hauptverfasser:	Cores, Ángel, Piquero, Marta, Villacampa, Mercedes, León, Rafael, Menéndez, J Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System Agents - isolation & purification Central Nervous System Agents - therapeutic use Degeneration Drug Discovery Gene Expression Regulation - drug effects Humans KEAP1 Molecular Targeted Therapy - methods Nervous system neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - drug effects NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NRF2 regulation NRF2–ARE pathway oxidative stress Proteolysis - drug effects Review
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Zusammenfassung:	NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom10060904