Prognostic Indicators for Ebola Patient Survival

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission an...

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Veröffentlicht in:Emerging infectious diseases 2016-02, Vol.22 (2), p.217-223
Hauptverfasser: Crowe, Samuel J, Maenner, Matthew J, Kuah, Solomon, Erickson, Bobbie Rae, Coffee, Megan, Knust, Barbara, Klena, John, Foday, Joyce, Hertz, Darren, Hermans, Veerle, Achar, Jay, Caleo, Grazia M, Van Herp, Michel, Albariño, César G, Amman, Brian, Basile, Alison Jane, Bearden, Scott, Belser, Jessica A, Bergeron, Eric, Blau, Dianna, Brault, Aaron C, Campbell, Shelley, Flint, Mike, Gibbons, Aridth, Goodman, Christin, McMullan, Laura, Paddock, Christopher, Russell, Brandy, Salzer, Johanna S, Sanchez, Angela, Sealy, Tara, Wang, David, Saffa, Gbessay, Turay, Alhajie, Nichol, Stuart T, Towner, Jonathan S
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Sprache:eng
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Zusammenfassung:To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2202.151250