Correlation of Serum Uric Acid and Proteinuria in Patients with Type 2 Di-abetes Mellitus

Background: Diabetes mellitus is one of the most common and important metabolic diseases worldwide. Hperuricemia is associated with kidney damage manifested by glomerular hypertrophy and sclerosis. The aim of this study was evaluation of association between serum uric acid level and proteinuria in patients with type 2 diabetes mellitus. Methods: A total of 140 patients (48 men and 92 women) with type 2 diabetes mellitus were enrolled in the study. Demographic criteria as age, body mass index, serum uric acid level and 24 hours urine protein were measured in these patients. Finding: Mean of patients age was 59.8 ± 10 years. Uric acid level in patients with significant proteinuria (≥ 500 mg/24 h) and mild proteinuria (< 500 mg/24 h) were 6.70 ± 1.82 and 5.06 ± 1.46 mg/dl respectively (P < 0.001). Serum uric acid level had positive correlation with 24 hours urine protein, duration of diabetes and insulin treatment. Conclusion: In type 2 diabetes mellitus, serum uric acid level has positive correlation with proteinuria; so uric acid maybe has a role in progression of diabetic nephropathy.