EVALUATION OF IMMUNE INDICES IN PATIENTS WITH INDOLENT AND AGGRESSIVE NON HODKIN`S LYMPHOMAS

A survey of immunological indices in patients with non-Hodkin’s lymphomas was performed, including evaluation of lymphocyte subpopulations, functional activity of neutrophils, immunoglobulin levels in peripheral blood and cytokine concentrations in mononuclear blood cell cultures and blood serum. The study revealed depressed indices of cellular and humoral immunity, like as an imbalance in Th1/Th2 cytokine production. T cell immune deficiency in the patients with aggressive lymphomas was more expressed, being also combined with significant deviations in cytokine status, as compared to a group of patients with indolent lymphomas. (Med. Immunol., 2011, vol. 13, N 1, pp 67-72)