Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa

Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa

IntroductionNeuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been in...

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Veröffentlicht in:European psychiatry 2022-06, Vol.65 (S1), p.S90-S91
Hauptverfasser: Miranda-Olivos, R., Baenas, I., Pastor, A., Del Pino, A., Codina, E., Sánchez, I., Juaneda-Segui, A., Jimenez-Murcia, S., De La Torre, R., Soriano-Mas, C., Fernandez-Aranda, F.
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Sprache:eng
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Abstract
Anorexia
Anorexia nervosa
Endocannabinoids
nucleus accumbens
Oral Communication
resting-state functional connectivity
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Zusammenfassung:IntroductionNeuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been involved in rewarding aspects of food intake.ObjectivesTo identify nucleus accumbens (NAcc) functional connectivity with whole-brain comparing between individuals with AN and controls. Furthermore, in a sub-study, to explore the interaction between NAcc functional connectivity and peripheral AEA and 2-AG levels.MethodsA total of 60 adult women (18 to 56 years of age) took part in the present study. Twenty-six individuals belonged to the AN group (BMI
ISSN:0924-9338
1778-3585
DOI:10.1192/j.eurpsy.2022.269