Crystalline deposition in the cornea and conjunctiva secondary to long-term clofazimine therapy in a leprosy patient

A 30-year-old woman, case of lepromatous leprosy with recurrent type II lepra reaction, on tablet clofazimine 100 mg/ day was referred to us from dermatology clinic for brownish discoloration of conjunctiva. Careful literature search revealed that only one such case is reported by Font et al., [5] having estimated cumulative dose of clofazimine of 219 gm as compared to 891 gm in our patient In the case reported by Font et al., ultrastructural study of conjunctival biopsy demonstrated that many of fibroblasts and macrophages contained rectangular or rhomboidal empty spaces corresponding to crystals, which ranged from 1.5 to 7 x m in length.