Egyptian broomrape (Phelipanche aegyptiaca): From foe to friend? Evidence of high nutritional value and potential suitability for food use

•E.B. identifies as a novel, edible food source with high nutritional values.•Nutritional profile comparable to quinoa (proteins, reducing sugars, lipids).•Contains higher dietary fibers, ascorbic acid, antioxidant activity and minerals.•Low glycemic index, suitable for diabetic diet.•No significant toxic effect found in safety assessment. This study investigates the potential of Egyptian broomrape (E.B.; Phelipanche aegyptiaca, Pers.), a parasitic plant, as a novel food source. This study aimed at (i) determining E.B.’s nutritional parameters, (ii) studying the effect of 10 different hosts on these values, and (iii) assessing its safety through a toxicological evaluation in mice. The results showed that the host plant affects the parasite's nutritional composition. When developed on several hosts, E.B. has similar levels of proteins and total lipids as compared to quinoa seeds, as well as similar essential amino acids profile. However, the parasite shows substantially higher levels of dietary fibers than in quinoa (19.2–30.6 % DW, vs 7.1 % DW), total phenolic compounds (32.92–66.86 mg GAE/gr DW, vs 0.53 mg GAE/gr DW), ascorbic acid (3.1–6.0 mg/gr DW, vs 2.7 mg/gr DW), total ash (7.2–11.5 % DW, vs 2.6 % DW) and several minerals, but lower levels of reducing sugars (263–441 mg/gr DW, vs 479 mg/gr DW), indicating a potential for low glycemic index ingredients. The safety assessment in mice showed no significant toxic effects. These findings suggest that E.B. could be a valuable food source, warranting further investigation into its nutritional benefits and safety for human and animal consumption. [Display omitted]