Preferences and Priorities for Relapsed Multiple Myeloma Treatments Among Patients and Caregivers in the United States

This study aimed to describe patient and caregiver preferences for treatments of relapsed or refractory multiple myeloma (MM). A survey including discrete-choice experiment (DCE) and best-worst scaling (BWS) exercises was conducted among US patients with relapsed or refractory MM and their caregiver...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Patient preference and adherence 2022-03, Vol.16, p.573-585
Hauptverfasser: Auclair, Daniel, Mansfield, Carol, Fiala, Mark A, Chari, Ajai, Cole, Craig E, Kaufman, Jonathan L, Orloff, Gregory J, Siegel, David S, Zonder, Jeffrey A, Mange, Brennan, Yesil, Jennifer, Dalal, Mehul, Mikhael, Joseph R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study aimed to describe patient and caregiver preferences for treatments of relapsed or refractory multiple myeloma (MM). A survey including discrete-choice experiment (DCE) and best-worst scaling (BWS) exercises was conducted among US patients with relapsed or refractory MM and their caregivers. The DCE included six attributes with varying levels including progression-free survival (PFS), toxicity, and mode and frequency of administration. In addition, the impact of treatment cost was assessed using a fixed-choice question. The BWS exercise included 18 items (modes and frequency of administration, additional treatment convenience, and toxicity items). The survey was administered online to patients recruited from the Multiple Myeloma Research Foundation CoMMpass study (NCT01454297). The final samples consisted of 94 patients and 32 caregivers. Avoiding severe nerve damage was most important to patients, followed by longer PFS. Caregivers considered PFS to be the most important attribute. We estimate that a third or more of patients were cost-sensitive, meaning their treatment preference was altered based on cost implications. Caregivers were not cost-sensitive. The three most bothersome treatment features in the BWS exercise were risk of kidney failure, lowering white blood cell counts, and weakening the immune system. Patients with relapsed or refractory MM and their caregivers consider many factors including efficacy, toxicity, mode/frequency of administration, and cost in their decisions regarding treatment options. The study provides a basis for future Research on patient and caregiver treatment preferences, which could be incorporated into shared decision-making with physicians.
ISSN:1177-889X
1177-889X
DOI:10.2147/PPA.S345906