Inhibition of dengue virus serotype 2 in Vero cells with [Cu(2,4,5-triphenyl-1H-imidazole) 2(H2O)2].Cl2

Dengue fever and dengue hemorrhagic fever are transmitted to humans by the and mosquitoes, with an observed 30-fold increase in global incidence the last 50 years. Despite the tremendous efforts invested anti-dengue virus research, no clinically approved vaccine or antiviral chemotherapeutics are av...

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Veröffentlicht in:Infectious disease reports 2020-07, Vol.12 (Suppl 1), p.8744
Hauptverfasser: Sucipto, Teguh H, Martak, Fahimah
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Sprache:eng
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Zusammenfassung:Dengue fever and dengue hemorrhagic fever are transmitted to humans by the and mosquitoes, with an observed 30-fold increase in global incidence the last 50 years. Despite the tremendous efforts invested anti-dengue virus research, no clinically approved vaccine or antiviral chemotherapeutics are available for humans, and disease treatment is limited to supportive care. Over the years there has been a continuous interest in the chemistry of metal complexes with biological activity, including platinum complexes with antitumor activity and silver complexes with antimicrobial action. Aim of the project was to investigate [Cu(2,4,5-triphenyl-1 imidazole) (H O) ].Cl as antiviral compound that was further tested for inhibitory effect on the replication of dengue virus type 2 (DENV-2) in Vero cell. DENV-2 were infected in Vero cells and replication of virus was measured by Viral ToxGlo with selectivity index value (SI) and determined as the ratio of cytotoxic concentration 50 (CC ) to inhibitory concentration 50 (IC ) for compound. The standard curve between concentration of compound (μg/mL) and %viability of cells was analyzed by logarithmic correlation regression with regression equation. For infection rates, t-test was used to examine the statistical significances among the concentrations of compound. P
ISSN:2036-7430
2036-7449
2036-7449
DOI:10.4081/idr.2020.8744