Gut microbiota at different stages of cardiovascular disease continuum

Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF). Material and methods . The study included 64 patients (men, 71,9%) with CAD, 33 (m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika 2024-01, Vol.22 (12), p.3751
Hauptverfasser: Yafarova, A. A., Dementyeva, E. D., Zlobovskaya, O. A., Kiselev, A. R., Sheptulina, A. F., Ashniev, G. A., Zhamalov, L. M., Makarov, V. V., Yudin, S. M., Drapkina, O. M.
Format: Artikel
Sprache:eng ; rus
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF). Material and methods . The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype. Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p
ISSN:1728-8800
2619-0125
DOI:10.15829/1728-8800-2023-3751