Investigation of mediborol oxidation and development of the method for its identification in the dosage forms by thin layer chromatography

The urgency of the discussed issue is caused by the need to carry out a qualitative analysis of the method of mediborol neuroprotective agents in the dosage forms. The main aim of the study is to investigate the oxidation of hindered phenol mediborol in the presence of alkaline solution of potassium hexacyanoferrate (III) and to develop the method for identifying mediborol in the dosage forms using this reaction. The methods used in the study: To investigate the product of mediborol oxidation the authors have used the methods of UV, IR and NMR spectroscopy, elemental analysis, to analyze mediborol in the dosage forms the thin layer chromatography was applied. The results: The authors studied mediborol oxidation with an alkaline solution of potassium hexacyanoferrate (III). The reaction final product structure was found using physical and chemical methods. The authors developed the method for identifying mediborol in the dosage forms based on this reaction using the thin layer chromatography.