Successful treatment of lower urinary tract infections with oral fosfomycin: a report of three cases

Infections due to multidrug-resistant organisms continue to increase, and therapeutic options remain scarce. Given this challenge, it has become necessary to use older antimicrobials for treatment of these pathogens. We report three patients with lower urinary tract infections caused by Klebsiella p...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2015-06, Vol.48 (3), p.358-360
Hauptverfasser:	da Silva, Juliana Oliveira, Yu, Maria Cecilia Zorat, Doi, André, de Araujo, Maria Rita Elmor, Neto, Pedro Aurélio Mathiasi, Furtado, Guilherme Henrique Campos
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use beta-Lactamases - secretion Disk Diffusion Antimicrobial Tests Female Fosfomycin Fosfomycin - therapeutic use Humans Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology KPC-producing Klebsiella pneumoniae Male Middle Aged Treatment Outcome TROPICAL MEDICINE Urinary tract infection treatment Urinary Tract Infections - drug therapy Urinary Tract Infections - microbiology
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Zusammenfassung:	Infections due to multidrug-resistant organisms continue to increase, and therapeutic options remain scarce. Given this challenge, it has become necessary to use older antimicrobials for treatment of these pathogens. We report three patients with lower urinary tract infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae who were successfully treated with a seven-day course of oral fosfomycin monotherapy.
ISSN:	0037-8682 1678-9849 1678-9849 0037-8682
DOI:	10.1590/0037-8682-0289-2014