INFLUENCE OF UNFAVOURABLE ENVIRONMENTAL FACTORS UPON HEALTH OF WORKERS AND CORRECTION OF RESULTANT ALTERATIONS

Intensified formation of free radicals is one of the most important unfavourable consequences of factors of industry acting upon human organism. Under physiological conditions, antioxidative system preserves from harmful influence of free radicals. To avoid a disturbing influence of oxidative stress upon the processes of human homeosthasis, additional quantities of antioxidants are indispensable. Dynamics of alterations of markers of oxidative stress caused by unfavourable industrial factors of metal processing (chemical agents, vibration, noise) under impact of native biomodulators were studied using native pollen. The programme was performed on 50 workers of metal processing, 9 males and 41 female, who used pollen during a period of 1 month. Control group consisted of 57 persons, 10 males and 47 females living and working under the same conditions. Blood tests (diene conjugates, malonic dialdehyde and katalase) using spectrophotometric methodology were studied before and after the course of treatment. After the treatment, contents of metabolites of lipid peroxidation, diene conjugates and malonic dialdehyde in blood serum essentially reduced. Activity of catalase decreased significantly in blood serum of males and regularly smoking females. In conclusion, presented data demonstrate antioxidative efficiency of native pollen and suggest more often applying of native biomodulators in cases with alterated processes of homeosthasis under impact of unfavourable environmental factors.