Derivation of the human embryonic stem cell line RCM1

The human embryonic stem cell line RCM-1 was derived from a failed to fertilise egg undergoing parthenogenetic stimulation. The cell line shows normal pluripotency marker expression and differentiation to three germ layers in vitro and in vivo. It has a normal 46XX female karyotype and microsatellit...

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Veröffentlicht in:	Stem cell research 2016-03, Vol.16 (2), p.476-480
Hauptverfasser:	De Sousa, P.A., Tye, B.J., Sneddon, S., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Gardner, J., Downie, J.M., Courtney, A., Brison, D.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured Cellular Reprogramming Comparative Genomic Hybridization Embryoid Bodies - cytology Female Flow Cytometry Histocompatibility Testing Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Human Embryonic Stem Cells - transplantation Humans Karyotype Mice Mice, SCID Microsatellite Repeats - genetics Microscopy, Fluorescence Ovum - cytology Teratoma - metabolism Teratoma - pathology Transcription Factors - genetics Transcription Factors - metabolism Transplantation, Heterologous
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Beschreibung
Zusammenfassung:	The human embryonic stem cell line RCM-1 was derived from a failed to fertilise egg undergoing parthenogenetic stimulation. The cell line shows normal pluripotency marker expression and differentiation to three germ layers in vitro and in vivo. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data is available.
ISSN:	1873-5061 1876-7753
DOI:	10.1016/j.scr.2015.12.020