Dichotocejpins A-C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110

Three new diketopiperazines, dichotocejpins A-C (1-3), together with eight known analogues (4-11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR...

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Veröffentlicht in:	Marine drugs 2016-09, Vol.14 (9), p.164-164
Hauptverfasser:	Fan, Zhen, Sun, Zhang-Hua, Liu, Zhong, Chen, Yu-Chan, Liu, Hong-Xin, Li, Hao-Hua, Zhang, Wei-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - metabolism Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Cell Line, Tumor Crystallography, X-Ray cytotoxity deep-sea-derived fungus Dichotomomyces cejpii diketopiperazines Drug Screening Assays, Antitumor Fermentation Fungi - chemistry Geologic Sediments - microbiology Humans Magnetic Resonance Spectroscopy Marine Models, Molecular Molecular Conformation Spectrometry, Mass, Electrospray Ionization α-glucosidase
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Zusammenfassung:	Three new diketopiperazines, dichotocejpins A-C (1-3), together with eight known analogues (4-11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4-6, 10-11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC50 of 138 μM.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md14090164