Decarboxylation of 2-keto fatty acids by brain

An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid....

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Veröffentlicht in:	Journal of lipid research 1966-03, Vol.7 (2), p.270-276
Hauptverfasser:	Davies, W E, Hajra, A K, Parmar, S S, Radin, N S, Mead, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	2-ketostearic acid Adenosine Triphosphate - metabolism Animals ascorbic acid Ascorbic Acid - metabolism brain Brain - enzymology Brain - metabolism Carboxy-Lyases - metabolism decarboxylation Fatty Acids - metabolism Fumarates - metabolism fumaric acid In Vitro Techniques Iron - metabolism Keto Acids - metabolism Magnesium - metabolism NAD - metabolism pig Stearic Acids - metabolism Subcellular Fractions - metabolism Swine
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Beschreibung
Zusammenfassung:	An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylene-diaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids.
ISSN:	0022-2275
DOI:	10.1016/S0022-2275(20)39292-0