Expression and Clinical Significance of LC-3 and P62 
in Non-small Cell Lung Cancer

Expression and Clinical Significance of LC-3 and P62 
in Non-small Cell Lung Cancer

LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and de...

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Veröffentlicht in:Zhongguo fei ai za zhi 2018-06, Vol.21 (6), p.445-450
Hauptverfasser: Wang, Cong, Li, Yongwen, Li, Ying, Gong, Hao, Zhang, Hongbing, Yuan, Yin, Li, Weiting, Liu, Hongyu, Chen, Jun
Format: Artikel
Sprache:chi
Schlagworte:
Apoptosis
Autophagy
Cancer therapies
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - metabolism
Clinical significance
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
LC-3
Li Jin
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - metabolism
Male
Microtubule-Associated Proteins - metabolism
Middle Aged
Non-small cell lung cancer
P62
Prognosis
Protein expression
Proteins
Proto-Oncogene Proteins c-myc - metabolism
Survival analysis
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Zusammenfassung:LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and define the clinical-pathologic features. 66 cases of non-small cell lung cancer patients were employed. The expression of LC-3 and P62 were detected by immunohistochemistry. LC-3 was positive stained in 27 out of 66 cases (40.9%) and P62 was positive stained in 43 out of 66 cases (65.2%). LC-3 positive staining was more frequently in squamous cell carcinoma patients (P
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2018.06.04