The clinical significance of UBE2C gene in progression of renal cell carcinoma

Renal cell carcinoma (RCC), with high morbidity and mortality, is one of the top ten serious cancers. Due to limited therapies and little knowledge about the mechanism underlying RCC, overall survival of RCC patients is poor. UBE2C is a member of ubiquitin modification system and promotes carcinogen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of histochemistry 2021-03, Vol.65 (2)
Hauptverfasser:	Chen, Zhiping, Wang, Lanfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Renal Cell - diagnosis Carcinoma, Renal Cell - metabolism Cell Movement - physiology Cell Proliferation - physiology Disease Progression Female Gene Expression Regulation, Neoplastic - physiology Gene Ontology GO analysis Humans KEGG analysis Kidney Neoplasms - diagnosis Kidney Neoplasms - metabolism Male Prognosis Renal cell carcinoma Signal Transduction - physiology UBE2C Ubiquitin-Conjugating Enzymes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Renal cell carcinoma (RCC), with high morbidity and mortality, is one of the top ten serious cancers. Due to limited therapies and little knowledge about the mechanism underlying RCC, overall survival of RCC patients is poor. UBE2C is a member of ubiquitin modification system and promotes carcinogenesis in cancer, but its role in RCC is unknown. Based on the TCGA (The Cancer Genome Atlas) data, UBE2C was over-expressed in a total of 525 RCC tissues and displayed higher expression in advanced tissues (stage IV vs stage I, p
ISSN:	1121-760X 2038-8306 2038-8306
DOI:	10.4081/ejh.2021.3196