Angiotensin receptor blockers are associated with lower mortality than ACE inhibitors in predialytic stage 5 chronic kidney disease: A nationwide study of therapy with renin-angiotensin system blockade

Angiotensin receptor blockers are associated with lower mortality than ACE inhibitors in predialytic stage 5 chronic kidney disease: A nationwide study of therapy with renin-angiotensin system blockade

Dual renin angiotensin system (RAS) blockade using angiotensin-receptor blockers (ARBs) in combination with angiotensin converting enzyme inhibitors (ACEIs) is reported to improve proteinuria in both diabetic and non-diabetic patients. However, its renoprotective effect and safety remain uncertain i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2017-12, Vol.12 (12), p.e0189126-e0189126
Hauptverfasser: Lin, Chih-Ching, Wu, Yu-Te, Yang, Wu-Chang, Tsai, Min-Juei, Liu, Jia-Sin, Yang, Chi-Yu, Li, Szu-Yuan, Ou, Shuo-Ming, Tarng, Der-Cherng, Hsu, Chih-Cheng
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Angiotensin converting enzyme inhibitors
Angiotensin II receptor blockers
Biology and Life Sciences
Chronic kidney failure
Development and progression
Dosage and administration
Drug therapy
Medicine and Health Sciences
Mortality
People and Places
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Dual renin angiotensin system (RAS) blockade using angiotensin-receptor blockers (ARBs) in combination with angiotensin converting enzyme inhibitors (ACEIs) is reported to improve proteinuria in both diabetic and non-diabetic patients. However, its renoprotective effect and safety remain uncertain in patients with advanced chronic kidney disease (CKD). From January 1, 2000 through June 30, 2009, we enrolled 14,117 pre-dialytic stage 5 CKD patients with serum creatinine >6mg/dL and hematocrit
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0189126