Interaction effect between low birthweight and resistin gene rs1862513 variant on insulin resistance and type 2 diabetes mellitus in adulthood: Toon Genome Study

Aims/Introduction Gene–environment interactions are considered to critically influence type 2 diabetes mellitus development; however, the underlying mechanisms and specific interactions remain unclear. Given the increasing prevalence of low birthweight (LBW) influenced by the intrauterine environmen...

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Veröffentlicht in:	Journal of diabetes investigation 2024-06, Vol.15 (6), p.725-735
Hauptverfasser:	Yoshida, Ayaka, Takata, Yasunori, Tabara, Yasuharu, Maruyama, Koutatsu, Inoue, Shota, Osawa, Haruhiko, Sugiyama, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Birth weight Body mass index Cohort analysis Deoxyribonucleic acid Diabetes Diabetes mellitus (non-insulin dependent) Disease DNA Genes Genetic factors Genetic testing Genomes Genotype & phenotype Genotypes Glucose Hypotheses Insulin resistance Intrauterine exposure Low birthweight Malnutrition Maternal & child health Original Questionnaires Resistin Type 2 diabetes susceptibility genes World War II
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Zusammenfassung:	Aims/Introduction Gene–environment interactions are considered to critically influence type 2 diabetes mellitus development; however, the underlying mechanisms and specific interactions remain unclear. Given the increasing prevalence of low birthweight (LBW) influenced by the intrauterine environment, we sought to investigate genetic factors related to type 2 diabetes development in individuals with LBW. Materials and Methods The interaction between 20 reported type 2 diabetes susceptibility genes and the development of type 2 diabetes in LBW (
ISSN:	2040-1116 2040-1124 2040-1124
DOI:	10.1111/jdi.14163