Synthesis and characterization of barbitones as antimicrobial agents

Barbitones (3) were synthesised by the condensation of chalcones (2) with barbituric acid. The structure of the synthesized compounds were assigned on the basis of elemental analyses, IR, NMR and mass spectral studies. All the products were evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi. Kondenzacijom halkona (2) sa barbiturnom kiselinom sintetizovani su barbiturati (3). Struktura sintetizovanih jediwewa odredjena je na osnovu elementarne analize, IR, NMR i masene spektroskopije. In vitro je proucavana aktivnost svih produkata prema razlicitim sojevima bakterija i gljivica.