Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes

Diabetic retinopathy (DR) is a leading cause of vision loss and disability. Effective management of DR depends on prompt treatment and would benefit from biomarkers for screening and pre-symptomatic detection of retinopathy in diabetic patients. MicroRNAs (miRNAs) are post-transcriptional regulators...

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Veröffentlicht in:	Scientific reports 2021-02, Vol.11 (1), p.4136-4136, Article 4136
Hauptverfasser:	Santovito, Donato, Toto, Lisa, De Nardis, Velia, Marcantonio, Pamela, D’Aloisio, Rossella, Mastropasqua, Alessandra, De Cesare, Domenico, Bucci, Marco, Paganelli, Camilla, Natarelli, Lucia, Weber, Christian, Consoli, Agostino, Mastropasqua, Rodolfo, Cipollone, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163/2743/137/138 692/53/2421 692/699/2743/137/138 Biomarkers Blood vessels Diabetes Diabetes mellitus (non-insulin dependent) Diabetic retinopathy Gene expression Humanities and Social Sciences MicroRNAs miRNA multidisciplinary Post-transcription Retinopathy Science Science (multidisciplinary)
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Zusammenfassung:	Diabetic retinopathy (DR) is a leading cause of vision loss and disability. Effective management of DR depends on prompt treatment and would benefit from biomarkers for screening and pre-symptomatic detection of retinopathy in diabetic patients. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression which are released in the bloodstream and may serve as biomarkers. Little is known on circulating miRNAs in patients with type 2 diabetes (T2DM) and DR. Here we show that DR is associated with higher circulating miR-25-3p (P = 0.004) and miR-320b (P = 0.011) and lower levels of miR-495-3p (P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-83047-w