MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review

Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human dis...

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Veröffentlicht in:	International journal of molecular sciences 2017-09, Vol.18 (9), p.1960
Hauptverfasser:	Smolle, Maria Anna, Leithner, Andreas, Posch, Florian, Szkandera, Joanna, Liegl-Atzwanger, Bernadette, Pichler, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biomarkers, Tumor Biomedical materials Breast cancer Diagnostic systems Endometrial cancer Endometrium Fibrosarcoma - metabolism Gene expression Gene Expression Regulation, Neoplastic Hemangiosarcoma - metabolism Humans Leiomyosarcoma - metabolism Liposarcoma - metabolism MicroRNAs MicroRNAs - classification MicroRNAs - genetics MicroRNAs - metabolism miRNA Neurilemmoma - metabolism Osteosarcoma Prognosis Review Rhabdomyosarcoma - metabolism RNA, Messenger - genetics Sarcoma - diagnosis Sarcoma - genetics Sarcoma - metabolism Sarcoma, Synovial - metabolism Soft tissue sarcoma Tissues Tumors tumourigenesis
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Zusammenfassung:	Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms18091960