Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients

Pruritus is a common symptom in end-stage renal failure. Many patients suffer from this severe distressing symptom. Although several factors have been postulated to explain uremic pruritus, there is not any conclusive evidence for one of these factors. We aimed to evaluate serum levels of brain-derived nerve growth factor (BDNF), neurotrophin-4 (NT-4), serum calcium, phosphors and parathyroid hormone in uremic patients with pruritus and without pruritus compared to control subjects. One hundred twenty patients suffering from renal failure and 60 healthy subjects were included in the study. Serum BDNF and NT4 levels were determined by ELISA. The serum calcium, phosphorus, parathyroid hormone and hemoglobin were also evaluated. Serum BDNF was significantly higher in uremic patients with pruritus ( =0.0026) and uremic patients without pruritus ( =0.0294) than control subjects. In addition, NT-4 levels were significantly elevated in uremic patients with pruritus (