MicroRNA roles in beta-catenin pathway

β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt sig...

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Veröffentlicht in:	Molecular cancer 2010-09, Vol.9 (1), p.252-252, Article 252
Hauptverfasser:	Huang, Kai, Zhang, Jun-Xia, Han, Lei, You, Yong-Ping, Jiang, Tao, Pu, Pei-Yu, Kang, Chun-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis beta Catenin - genetics beta Catenin - metabolism Cancer Cellular signal transduction Gene expression Genetic aspects Humans Kinases MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Models, Biological Mutation Neoplasms - genetics Neoplasms - metabolism Neurosurgery Phosphorylation Physiological aspects Regulation Review Signal Transduction - genetics Signal Transduction - physiology Wnt Proteins - genetics Wnt Proteins - metabolism
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Beschreibung
Zusammenfassung:	β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.
ISSN:	1476-4598 1476-4598
DOI:	10.1186/1476-4598-9-252