An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.

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Veröffentlicht in:Beilstein journal of organic chemistry 2009-11, Vol.5 (1), p.66-66
Hauptverfasser: Sagyam, Rajeshwar Reddy, Buchikonda, Ravinder, Pitta, Jaya Prakash, Vurimidi, Himabindu, Padi, Pratap Reddy, Ghanta, Mahesh Reddy
Format: Artikel
Sprache:eng
Schlagworte:
1,4-diketone
Chemistry
Full Research Paper
migration and cyclization
pyrrolo[1,2-b]pyridazine
tertiary butyl carbamate
tertiary butyl carbazate
α,β-unsaturated ketone
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Zusammenfassung:The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.5.66