Astragaloside IV alleviates heart failure by modulating Nrf-2

Echocardiography analysis demonstrated that the percentage of EF was decreased in the rats with HF compared with the sham-operated rats. Remarkably, we showed that the HF-impaired expression of nuclear factor erythroid 2-related factor 2 (Nrf-2) and its downstream gene heme oxygenase-1 (HO-1) were rescued by treatment with AS-IV [Figure 1E]. Dox treatment increased the percentage of cells with low membrane potential, and AS-IV could attenuate this phenotype in the cells in a dosedependent manner [Figure 1G]. [...]Dox treatment markedly increased the expression of DRP1 but decreased the expression of mitofusin1 and mitofusin2, and AS-IV treatment reversed these effects [Figure 1H].