Sialendoscopy for treatment of major salivary glands diseases: a comprehensive analysis of published systematic reviews and meta-analyses

•Sialendoscopy was effective and safe in obstructive salivary glands diseases.•Although it was an effective intervention, studies showed important heterogeneity.•All reviews had critically low quality of evidence when using the AMSTAR-2 tool.•We still lack comparative observational and interventional studies in sialendoscopy.•Future reviews should follow guidelines to improve study conduction and reporting. Sialendoscopy is a minimally invasive procedure used to diagnose and treat obstructive salivary gland diseases. Previous studies in the topic have shown mixed results. The present study aimed to evaluate the efficacy and safety of sialendoscopy through previous systematic reviews for different outcomes of several diseases. We also aimed to assess studies’ methodological quality and heterogeneity. We conducted a comprehensive systematic literature search of Pubmed, Embase, Lilacs and Cochrane Library. We included systematic reviews and meta-analyses that used sialendoscopy to treat both lithiasic and alithiasic salivary glands diseases. Data extraction included studies’ characteristics and results. We assessed studies’ methodological quality using the AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews 2) tool. 13 studies were included in the review, being 9 in adult populations and 4 in pediatric populations. Sialendoscopy proved to be effective at the treatment of different lithiasic and other obstructive diseases, but with important heterogeneity. The technique was also considered highly safe in most studies. However, studies had a critically low quality of evidence. Most studies demonstrated high efficacy and safety of sialendoscopy, but with critically low quality of evidence. We still lack randomized studies in this field, and future systematic reviews on the topic should follow current guidelines to improve conduction and reporting.