Efficacy and safety of adjuvant topical application of botanicals in the treatment of melasma: A systematic review and meta-analysis

To systematically evaluate the efficacy and safety of topical application of botanical (TAB) adjuvants in the treatment of melasma and provide evidence-based medical evidence for their clinical application. Medline, Web of Science, EMBASE, Cochrane Library, CNKI, VIP, Wanfang Data, and SinoMed, data...

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Veröffentlicht in:Heliyon 2024-03, Vol.10 (6), p.e28096-e28096, Article e28096
Hauptverfasser: Guo, Lin, Zhang, Yuanxin, Wu, Siqing, Bai, Ming, Tian, Shuo, Miao, Mingsan
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Sprache:eng
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Zusammenfassung:To systematically evaluate the efficacy and safety of topical application of botanical (TAB) adjuvants in the treatment of melasma and provide evidence-based medical evidence for their clinical application. Medline, Web of Science, EMBASE, Cochrane Library, CNKI, VIP, Wanfang Data, and SinoMed, databases were searched to identify all randomized controlled clinical trials on TAB adjuvant treatment for melasma from inception to May 2023. The primary outcomes included clinical efficacy, adverse effects, recurrence rate, and melanin index. Subgroup analyses were performed using the Melasma Area Severity Index (MASI) scores. This study included 16 randomized trials with 1386 participants. Eligible trials demonstrated that topical phytomedicine adjuvant treatment for melasma increased clinical effectiveness (RR = 1.14, 95% CI (1.10, 1.19), P <0.00001), decreased recurrence rate (RR = 0.28, 95% CI (0.13, 0.59), P = 0.0009), and decreased melanin index (MI) (MD = −22.2,95% CI (−31.79, −12.61), P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e28096